Ne content material of the AD group was greater than that from the cascular dementia group (Figure ).Discussion Homocysteine is definitely an intermediate item of methionine metabolism.A lot of studies showed that homocysteine was an independent danger element for coronary artery illness, cerebrovascular disease, peripheral vascular illness and other folks.Some research held that hyperhomocysteinemia played a role inside the occurrence and development of AD.Studies have shown that higher homocysteine brought on cognitive function and resulted in AD, which may well be related with biochemical harm caused by oxidative anxiety .Higher levels of homocysteine can markedly enhance the content of oxygen no cost radicals and promote the formation of nitric oxide.Higher levels of nitric oxide can turn out to be neurotoxic substances .Oxygen free radicals can promote schizolysis of APP ( amyloid protein precursor) and formation of A amyloid protein, therefore escalating the generation and deposition of A, which can be the primary pathological change in AD.Our study result showed that when the AD group was compared with all the typical control group, the MMSE score was lower plus the homocysteine content greater, having a statistically substantial distinction between the two groups (P ).When the AD group was compared with the vascular dementia group, the MMSE scores were not significantly diverse amongst the two groups (P ); the homocysteine content material in the AD group was reduced than that with the vascular dementia group, using a statistically significant difference (P ).As outlined by the complete outcome in the above documents, it was normally regarded as that the MMSE score and homocysteine content material may very well be employed as one particular of the PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21593114 indicators to distinguish AD and regular elderly subjects, and also the homocysteine content material as one on the indicators to distinguish AD and vascular dementia.The outcome of our metaanalysis was limited in the following elements firstly, although our study integrated publications, we did not make stratified evaluation on gender and distinctive ages, so we could not see extra detailed outcome; secondly, there existed selection bias that couldn’t be excluded and also the influence of confounding factors that could not be determined; furthermore, there existed methodological defects in publications integrated in our metaanalysis, including not clearly explaining random approach, blinding strategy and other folks, which affected our analysis outcomes.It truly is held in evidencebased medicine that the evidence obtained from randomized controlled clinical trials has the strongest authenticity and reliability; plus the complete conclusion is far more convincing from systematic evaluation on multiple RCT and metaanalysis, as compared with single RCT.Most studies integrated in our evaluation are retrospective casecontrol research and do not belong to the RCT category in the strict sense, which directly affects the demonstration strength of our metaanalysis outcome.In the future, when making systematic evaluation on multicenter RCT studies among elderly people today, we are OLT1177 Inhibitor hopeful to obtain conclusive evidence on the partnership in cognitive function between homocysteine and AD, then providing directions to clinical practice and producing clinical intervention technique more rational.Disclosure of conflict of interest None.Address correspondence to Dr.Yuan Zhong, Department of Geriatrics, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Yishan Road, Shanghai , China.Tel ; Email [email protected]
ORIGINAL Research Post Victimisation and PT.