Mouse VSTM5 Protein 3648

Additional Information:
inaccessionQ9D806|express systemHEK293|product tagC-hFc|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundV-set and transmembrane domain-containing protein 5 (Vstm5), a cell-adhesion-like molecule belonging to the Ig superfamily, was found in mouse brain. Knock-down of Vstm5 in cultured hippocampal neurons markedly reduced the complexity of dendritic structures, as well as the number of dendritic filopodia. Vstm5 also regulates neuronal morphology by promoting dendritic protrusions that later develop into dendritic spines.|molecular weightThe protein has a predicted MW of 40.1 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Mouse VSTM5 Protein 3648proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceV-set and transmembrane domain-containing protein 5 (Vstm5), a cell-adhesion-like molecule belonging to the Ig superfamily, was found in mouse brain. Knock-down of Vstm5 in cultured hippocampal neurons markedly reduced the complexity of dendritic structures, as well as the number of dendritic filopodia. Vstm5 also regulates neuronal morphology by promoting dendritic protrusions that later develop into dendritic spines.Protein namesV-set and transmembrane domain-containing protein 5Gene namesVstm5,Vstm5Mass10090DaFunctionCell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain.Subellular locationCell membrane ; Single-pass type I membrane protein. Cell projection, dendrite. Cell projection, axon .TissuesHighly expressed in the central nervous system (CNS), with the highest expression in thalamus, hippocampus, cerebrum, midbrain and spinal cord. Also highly expressed in stomach, kidney and small intestine.StructureCan homooligomerize through cis interactions within the same cell membrane.Post-translational modificationN-glycosylated.Target Relevance information above includes information from UniProt accession: Q9D806The UniProt Consortium|