Name :
LRP-5 Protein
Description :
A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis.
Species :
Human
Uniprotkb :
HEK293
Tag :
C-hFc
Synonyms :
EVR1, BMND1, BMND1OPTA1, LRP5, LRP7, OPPG, EVR4, OPTA1, OPS, HBM, VBCH2, LR3VBCH2, LRP-7, LR3, LRP-5
Construction :
Recombinant Human LRP-5 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Glu644-Gln1263.[Accession |O75197-1]
Protein Purity :
> 95% as determined by Tris-Bis PAGE
Molecular Weight :
The protein has a predicted MW of 96.51 kDa. Due to glycosylation, the protein migrates to 100-115 kDa based on Tris-Bis PAGE result.
Endotoxin :
Less than 1EU per μg by the LAL method.
Formulatione :
Supplied as 0.22μm filtered solution in PBS, 100mM L-arginine (pH 7.4).
Reconstitution :
Stability & Storage :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background :
A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis.
References and Literature :
1. Williams BO. LRP5: From bedside to bench to bone. Bone. 2017 Sep;102:26-30. doi: 10.1016/j.bone.2017.03.044. Epub 2017 Mar 2 PMID: 28341377.
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