**Background** Cytochrome P450 (CYP) enzymes play a critical role in the metabolism of a wide array of endogenous compounds and exogenous drugs. Among these, the CYP3A subfamily is the most…
**Background** Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that can undergo rearrangement, leading to the expression of EML4-ALK fusion proteins. This oncogenic driver is frequently found in a…
**Background** The sigma-1 receptor ($\sigma_1$R) is a unique chaperone protein located primarily in the endoplasmic reticulum membrane, playing a critical role in modulating calcium signaling, protein folding, and cellular stress…
**Background** Breast cancer remains one of the most prevalent and lethal malignancies among women worldwide. A critical challenge in cancer therapy is the evasion of apoptosis, a programmed cell death…
**Background** Aplastic anemia is a severe bone marrow failure syndrome characterized by pancytopenia and a significant reduction in hematopoietic stem cells. This condition leads to a critical deficiency in white…
**Background** Phospholipase A2 (PLA2) is a critical enzyme that catalyzes the hydrolysis of phospholipids, releasing arachidonic acid and other lipid mediators that play pivotal roles in inflammatory responses and cellular…