8839;ten.1074/jbc.M112.348839. 21. Barfod L, Bernasconi 18055761 NL, Dahlback M, Jarrossay D, Andersen PH et al. Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA. Mol buy BTZ-043 Microbiol 63: 335347. MMI5503;10.1111/j.1365-2958.2006.05503.x. 22. Tutterrow YL, Avril M, Singh K, Long CA, Leke RJ et al. Higher levels of antibodies to various domains and strains of VAR2CSA correlate with all the absence of placental malaria in Lecirelin Cameroonian ladies living in an area of high Plasmodium falciparum transmission 19. Infect Immun 80: 14791490. IAI.00071-12;10.1128/IAI.00071-12. 23. Muyldermans S Single domain camel antibodies: current status. J Biotechnol 74: 277302. S1389-035200021-6. 24. De Genst EJ, Guilliams T, Wellens J, O’Day EM, Waudby CA et al. Structure and properties of a complicated of alpha-synuclein and a single-domain camelid antibody 26. J Mol Biol 402: 326343. S0022-283600742-4;10.1016/j.jmb.2010.07.001. 25. Stijlemans B, Conrath K, Cortez-Retamozo V, Van XH, Wyns L, et al. Effective targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm. J Biol Chem 279: 1256 1261. 10.1074/jbc.M307341200;M307341200. 26. Muyldermans S, Baral TN, Retamozzo VC, De BP, De GE, et al. Camelid immunoglobulins and nanobody technology 106. Vet Immunol Immunopathol 128: 178183. S0165-242700401-7;10.1016/j. vetimm.2008.10.299. 27. Saerens D, Conrath K, Govaert J, Muyldermans S Disulfide bond introduction for general stabilization of immunoglobulin heavy-chain variable domains 59. J Mol Biol 377: 478488. S0022-283600040-5;10.1016/ j.jmb.2008.01.022. 28. Harmsen MM, de Haard HJ Properties, production, and applications of camelid single-domain antibody fragments. Appl Microbiol Biotechnol 77: 13 22. ten.1007/s00253-007-1142-2. 29. Barfod L, Dobrilovic T, Magistrado P, Khunrae P, Viwami F et al. Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by many variants. J Immunol 185: 75537561. jimmunol.1002390;ten.4049/jimmunol. 1002390. 30. Minaeian S, Rahbarizadeh F, Zarkesh-Esfahani SH, Ahmadvand D, Broom OJ Neutralization of human papillomavirus by particular nanobodies against major capsid protein L1 98. J Microbiol Biotechnol 22: 721728. JMB022-05-20. 31. Muyldermans S, Atarhouch T, Saldanha J, Barbosa JA, Hamers R Sequence and structure of VH domain from naturally occurring camel heavy chain immunoglobulins lacking light chains. Protein Eng 7: 11291135. 32. Wesolowski J, Alzogaray V, Reyelt J, Unger M, Juarez K et al. Single domain antibodies: promising experimental and therapeutic tools in infection and immunity 6. Med Microbiol Immunol 198: 157174. 10.1007/s00430-0090116-7. 33. Khunrae P, Dahlback M, Nielsen MA, Andersen G, Ditlev SB et al. Fulllength recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies. J Mol Biol 397: 826834. S0022-283600086-0;10.1016/j.jmb.2010.01.040. 34. Conrath KE, Lauwereys M, Galleni M, Matagne A, Frere JM et al. Betalactamase inhibitors derived from single-domain antibody fragments elicited within the camelidae 73. Antimicrob Agents Chemother 45: 28072812. 10.1128/ AAC.45.10.2807-2812.2001. 35. Hmila I, Abdallah RB, Saerens D, Benlasfar Z, Conrath K et al. VHH, bivalent domains and chimeric Heavy chain-only antibodies with higher neutralizing efficacy for scorpion toxin AahI’ 15. Mol Immunol 45: three.8839;ten.1074/jbc.M112.348839. 21. Barfod L, Bernasconi 18055761 NL, Dahlback M, Jarrossay D, Andersen PH et al. Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA. Mol Microbiol 63: 335347. MMI5503;10.1111/j.1365-2958.2006.05503.x. 22. Tutterrow YL, Avril M, Singh K, Long CA, Leke RJ et al. High levels of antibodies to various domains and strains of VAR2CSA correlate using the absence of placental malaria in Cameroonian women living in an region of high Plasmodium falciparum transmission 19. Infect Immun 80: 14791490. IAI.00071-12;ten.1128/IAI.00071-12. 23. Muyldermans S Single domain camel antibodies: present status. J Biotechnol 74: 277302. S1389-035200021-6. 24. De Genst EJ, Guilliams T, Wellens J, O’Day EM, Waudby CA et al. Structure and properties of a complicated of alpha-synuclein as well as a single-domain camelid antibody 26. J Mol Biol 402: 326343. S0022-283600742-4;ten.1016/j.jmb.2010.07.001. 25. Stijlemans B, Conrath K, Cortez-Retamozo V, Van XH, Wyns L, et al. Effective targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm. J Biol Chem 279: 1256 1261. ten.1074/jbc.M307341200;M307341200. 26. Muyldermans S, Baral TN, Retamozzo VC, De BP, De GE, et al. Camelid immunoglobulins and nanobody technology 106. Vet Immunol Immunopathol 128: 178183. S0165-242700401-7;ten.1016/j. vetimm.2008.ten.299. 27. Saerens D, Conrath K, Govaert J, Muyldermans S Disulfide bond introduction for common stabilization of immunoglobulin heavy-chain variable domains 59. J Mol Biol 377: 478488. S0022-283600040-5;ten.1016/ j.jmb.2008.01.022. 28. Harmsen MM, de Haard HJ Properties, production, and applications of camelid single-domain antibody fragments. Appl Microbiol Biotechnol 77: 13 22. ten.1007/s00253-007-1142-2. 29. Barfod L, Dobrilovic T, Magistrado P, Khunrae P, Viwami F et al. Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally critical antibody epitopes shared by a number of variants. J Immunol 185: 75537561. jimmunol.1002390;10.4049/jimmunol. 1002390. 30. Minaeian S, Rahbarizadeh F, Zarkesh-Esfahani SH, Ahmadvand D, Broom OJ Neutralization of human papillomavirus by specific nanobodies against key capsid protein L1 98. J Microbiol Biotechnol 22: 721728. JMB022-05-20. 31. Muyldermans S, Atarhouch T, Saldanha J, Barbosa JA, Hamers R Sequence and structure of VH domain from naturally occurring camel heavy chain immunoglobulins lacking light chains. Protein Eng 7: 11291135. 32. Wesolowski J, Alzogaray V, Reyelt J, Unger M, Juarez K et al. Single domain antibodies: promising experimental and therapeutic tools in infection and immunity six. Med Microbiol Immunol 198: 157174. 10.1007/s00430-0090116-7. 33. Khunrae P, Dahlback M, Nielsen MA, Andersen G, Ditlev SB et al. Fulllength recombinant Plasmodium falciparum VAR2CSA binds particularly to CSPG and induces potent parasite adhesion-blocking antibodies. J Mol Biol 397: 826834. S0022-283600086-0;10.1016/j.jmb.2010.01.040. 34. Conrath KE, Lauwereys M, Galleni M, Matagne A, Frere JM et al. Betalactamase inhibitors derived from single-domain antibody fragments elicited within the camelidae 73. Antimicrob Agents Chemother 45: 28072812. 10.1128/ AAC.45.10.2807-2812.2001. 35. Hmila I, Abdallah RB, Saerens D, Benlasfar Z, Conrath K et al. VHH, bivalent domains and chimeric Heavy chain-only antibodies with higher neutralizing efficacy for scorpion toxin AahI’ 15. Mol Immunol 45: three.