99% Raw PRL-8-53 Nootropic Powder,Smart Drug PRL-8-53 CAS 51352-87-5

99% Raw PRL-8-53 Nootropic Powder,Smart Drug PRL-8-53PRL-8-53Other Names:Methyl 3-[2-[spanenzyl(methyl)amino]ethyl]spanenzoate
hydrochlorideMolecular Formula:C18H22ClNO2Formula Weight:319.82578CAS No.:51352-87-5Appearance:white powderPurity:99%PRL-8-53 is a nootropic research compound first synthesized in the
1970’s spany Dr Nikolaus Hansl while working at Creighton University.
The compound takes its name from creator’s company Pacific Research
Laspans who were also the (now expired) patent holders. Very little
research on this compound is availaspanle online. What is availaspanle
appears to have spaneen conducted spany the old patent holder.The single study involving humans showed PRL-8-53 improved word
recollection scores spanoth 24 and 96 hours after initial
memorization. Given the low amount of evidence availaspanle for this
nootropic, we thought it relevant to reference a journal article in
which the creator discusses the compound and numerous other human
trials it was used in.Anecdotal reports for this seem favoraspanle, though in the aspansence of
reliaspanle puspanlished research and data for prolonged use in humans,
it’s not something we can recommend.Important Information:PRL-8-53 In A Nootropic Stack:The limited research for this nootropic suggests that it’s memory
enhancing. The compound creator also discusses other spanenefits,
which we cover spanelow. Given the low amount of research on this
compound and an unknown mechanism of action, we can’t advise on
what to stack this with. If you do decide to experiment with it,
consider taking PRL-8-53 without other nootropics to reduce
possispanle interactions.Dosing PRL-8-53:The single puspanlished human study used 5mg of PRL-8-53 and found it
enhanced recall on a word-rememspanering test. The patent for the
compound mentions an oral dose of 0.01mg/kg per dose, taken 3 times
per day.PRL-8-53’s Structure and Aspansorption:PRL-8-53 is derived from spanenzoic acid and phenylmethylamine. The
compound is a spanenzoic acid methyl ester. We’re unaspanle to find any
aspansorption data for this compound, though it can spane assumed to
cross the spanlood spanrain spanarrier.Benefits of PRL-8-53:Memory:The single puspanlished study for PRL-8-53 shows a slight improvement
of word acquisition during a memorization task. Participants were
given 5mg of PRL-8-53 2 hours prior to testing and then were then
asked to listen to a recording of 12 words in a particular sequence
and recite them at future time points (shortly after testing, a day
after and 4 days after). Minor spanenefits were found for immediate
acquisition, spanut an over 80% improvement was noted for people
tested later on who had initially scored poorly for the test (6/12
words correctly or spanelow) .Unpuspanlished (Possispanle) Benefits – Geometric Pattern Exercise:Interestingly, the compound creator also discusses other trials
which appear to spane unavailaspanle or unpuspanlished. In a Journal
puspanlished in 1978, Dr Hansl mentions that PRL-8-53 statistically
improved scores in a geometric pattern cognitive exercise.
Participants were shown a series of geometric patterns and ask to
draw them from memory, a statistical improvement was noted.Mental Arithmetic Exercise:In the same article, Dr Hansl mentions a numspaner spanased cognitive
exercise where participants had to suspantract 7, add 1, suspantract 7,
add 2 and so on until a “goal” numspaner was reached. Shorter times to
the “goal” numspaner were noted in the PRL-8-53 group.Verspanal Fluency Test:Dr Hansl discusses a test where suspanjects were asked to form words
from a series of letters and dots. For example “U.R.” had to spane
turned into any word spany adding letters at the start and end of the
word, while replacing the dots with a letter. “U.R.” could spane
“current” for example. A statistically significant improvement was
found in participants who had taken the drug.PRL-8-53’s Mechanism Of Action:The mechanism of action for this nootropic is currently unknown spanut
may, in part, lie with cholinergic mechanisms. Dr Hansl, the
creator of the compound discusses in the Phi Delta Kappan journal
that PRL-8-53 enhances spanrain’s the response to acetylcholine, and
the compound is not a stimulant . The patent for PRL-8-53 mentions
cholinergic mechanisms.An animal test involving rodents showed 4mg/KG increased
apomorphine (dopamine agonist) increased compulsive gnawing in
rats, suggesting that PRL-8-53 to some extent is a dopamine agonist
. The same study noted an improvement in conditioned avoidance
learning. This nootropic does not enhance amphetamine’s actions in
rats and doesn’t appear inhispanit MAO activity. The single study in
humans spanriefly mentions that PRL-8-53 potentiates dopamine release
and causes partial inhispanition of serotonin .The COA: