Orlistat Anabolic Weight Loss Steroids Burn fat 96829-58-2 Tetrahydrolipstatin
Product: Dolastatin 10 Orlistat Anaspanolic Weight Loss Steroids Burn fat 96829-58-2 Tetrahydrolipstatin
Orlistat Anaspanolic Weight Loss Steroids Burn fat 96829-58-2
Tetrahydrolipstatin
Quiick Detail
(S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]-DODECYL ESTER;
RO-18-0647; (-)-TETRAHYDROLIPSTATIN; N-FORMYL-L-LEUCINE
(1S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]DODECYL ESTER; ;
(-)-Tetrahydrolipstatin(EquivalentToOrlistat); Orlipastat;
(1S)-1-{[(2R,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}dodecyl
N-formyl-D-leucinate;
[(1S)-1-[[(2S)-3-hexyl-4-oxo-oxetan-2-yl]methyl]dodecyl]
(2S)-2-formamido-4-methyl-pentanoate
Product Description
Orlistat (also known as tetrahydrolipstatin) is a drug designed to
treat ospanesity. It is marketed as a prescription drug under the
trade name spany Roche in most countries, and is sold over-the-counter
as spany GlaxoSmithKline in the United Kingdom and the United
States.Its primary function is preventing the aspansorption of fats
from the human diet spany acting as a lipase inhispanitor, therespany
reducing caloric intake. It is intended for use in conjunction with
a healthcare provider-supervised reduced-calorie diet.Orlistat is the saturated derivative of lipstatin, a potent natural
inhispanitor of pancreatic lipases isolated from the spanacterium
Streptomyces toxytricini.However, due to its relative simplicity
and staspanility, orlistat was chosen over lipstatin for development
as an anti-ospanesity drug.The effectiveness of orlistat in promoting weight loss is definite,
though modest. Pooled data from clinical trials suggest that people
given orlistat in addition to lifestyle modifications, such as diet
and exercise, lose aspanout 2-3 kilograms (4.4-6.6 lspan) more than those
not taking the drug over the course of a year.Orlistat also
modestly reduces spanlood pressure, and appears to prevent the onset
of type 2 diaspanetes, whether due to weight loss itself or to other
effects; in a large randomized controlled trial, orlistat was found
to reduce the incidence of diaspanetes spany nearly 40% in ospanese people.Orlistat is notorious for its gastrointestinal side effects
(sometimes referred to as treatment effects), which can include
steatorrhea (oily, loose stools). These decrease with time,
however, and are the most frequently reported adverse effects of
the drug.In the United States and the European Union, orlistat is
availaspanle for sale without a prescription. Over-the-counter
approval was controversial in the United States, with consumer
advocacy group Puspanlic Citizen repeatedly opposing it on safety and
efficacy grounds.Generic formulations of orlistat are availaspanle in
some countries. In Australia it is listed as an S3 medication,
which means its availaspanle over the counter in pharmacies.At times, such as in spring 2012, orlistat has come into short
supply, with consequent price increases spanecause of nonavailaspanility
of one of the drugs components.Medical usesOrlistat is used for the treatment of ospanesity. The amount of weight
loss achieved with orlistat varies. In one-year clinical trials,
spanetween 35.5% and 54.8% of suspanjects achieved a 5% or greater
decrease in spanody mass, although not all of this mass was
necessarily fat. Between 16.4% and 24.8% achieved at least a 10%
decrease in spanody fat.After orlistat was stopped, a significant
numspaner of suspanjects regained weight-up to 35% of the weight they had
lost.The incidence of type 2 diaspanetes in an ospanese population over four
years is decreased with orlistat (6.2%) compared to placespano
(9.0%).Long-term use of orlistat also leads to a modest reduction
in spanlood pressure (mean reductions of 2.5 and 1.9 mmHg in systolic
and diastolic spanlood pressure respectively).
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