E ordinal logistic regression evaluation with backward choice was used to select the set of covariates that had been independently linked using the outcome.Pvalues of much less than .on twotailed tests had been regarded as statistically considerable.Benefits A total of ( female, male) individuals enrolled in our study.Female to male ratio was .The mean age on the sufferers and imply age at disease onset had been ..and ..years, respectively.Benefits of univariate analysis Amongst demographic characteristics, gender, younger age at onset, good household history, and parental consanguinity were not associated with disease severity.Nevertheless, a weak connection was detected amongst education and illness severity (Table).Amongst clinical components, presenting Hypericin Autophagy symptoms for instance difficulty in walking, polysymptomatic attacks, and upper and lower extremity dysfunction were associated with greater disability.In contrast, presenting optic neuritis had greater prognosis (Table).Comprehensive recovery soon after the very first attack, longer interval between the first and second attacks, fewer symptoms at presentation, shorter disease duration, and relapsingremitting course have been associated with much less disability and greater prognosis (Table and).Benefits of multivariate analysis Ordinal logistic regression showed extra extreme disease to become associated with increasing age of onset, larger number of presenting symptoms, havingBaghizadeh et al.ijnl.tums.ac.ir January …………………………Years ……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………EDSS …………………………Figure .Matrixes of Expanded Disability Status Scale (EDSS) score as a function of illness duration displaying the distribution of Several Sclerosis Severity Score (MSSS) deciles Table .Illness severity subgroups according to the Multiple Sclerosis Severity Score (MSSS), MSSS Benign .Mildmoderate ..Advancedaccelerated ..Aggressivemalignant .Table .Associations of demographic aspects and disease severity MildTotal Chronic moderate Gender Male Female Illiterate Parental consanguinity No Yes Constructive family history No YesAdvancedaccelerated Aggressivemalignant P ..Education (years) ..Depending on MannWhitney testBased on Spearman correlation Ir J neurol ; Demographic variables affecting MS severityijnl.tums.ac.ir JanuaryTable .Associations in the presenting symptoms and illness severity MildTotal Chronic moderate Polysymptomatic onset Difficulty in walking Lower extremity dysfunction Upper extremity dysfunction Reduced visual acuity (optic neuritis) Sexual dysfunction Bladderbowel dysfunction Fatigue Sensory symptoms (discomfort, paresthesia, Lhermitte’s sign) Facial motor symptoms Facial sensory symptoms Oculomotor impairment Vertigo, hypoacousia Speechswallowing impairment Mental deterioration Psychiatric symptoms Paroxysmal symptoms Advancedaccelerated PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21598963 Aggressivemalignant P ……………..According to MannWhitney testTable .Associations of illness course and attack properties with disease severity MildAdvancedTotal Ch.