Oned3 cycles, 10 min day for 1 dayAt the same time as reperfusionBilateral femoral arteriesp38MAPK signal pathway(80)(Continued)Frontiers in Neurology | www.frontiersin.org 7 February 2018 | Volume 9 | ArticleChen et al.TABLe 1 | Continued Animal Sex, age, body weight Male, 9 weeks old, 29020 g ischemic organ Heart Anesthetic made use of before ischemia Pentobarbital 60 mgkg Anesthetic used in the course of RiC Not described RiC protocolday when RiC was began RiC organ Main pathway investigated pioid receptors ReferenceSD rats1 cycle, 10 min ischemia, 5 min reperfusionday for 1 dayTwo hind limbs At 15 min after left coronary artery ligation, and limb blood provide was restored five min just before loosening the left coronary artery ligation for myocardial reperfusion. At 24 h right after hypoxia ischemia. Heart ischemia was induced immediately after LRIpreC At 24 h just before ischemia Brain ischemia was induced immediately after LRIpreC Brain ischemia was induced at 1 h right after LRIpreC Hind limb(81)SD ratsUnsexed Brain pups, ten days Male, 10 days old Heart3 Isoflurane and maintained with 1.5 3 Isoflurane and maintained with 1.five Pentobarbital 70 mgkg 5 Isoflurane and maintained with two four Isoflurane and maintained with 21.5 Isoflurane4 cycles, ten min day for 1 day 4 cycles, five minday for 1 dayNo specific pathway pointed out By systemic releasing of microRNA(66)Limb remote ischemic preconditioning (LRIpreC)C57BL6 micePentobarbital 60 mgkgHind limb(82)C57BL6 mice SD ratsMale, 92 weeks Male, 25050 g Male, 280Heart BrainNot mentioned 2 Isoflurane 2 Isoflurane3 cycles, 5 minday for 1 day 3 cycles, 15 min day for 1 day three cycles, 5 minday for 1 2-Phenylacetaldehyde Technical Information dayLeft femoral artery Left hind limbBy upregulating IL10 No distinct pathway pointed out Rely around the activation of adenosine A1 receptors and by reduction in oxidative stress, inflammation and endogenous antioxidant preservation No particular pathway described(83) (84)SD ratsBrainRight hind limb(85)Wistar ratsMale, 25080 gBrain10 Chloral HydrateNot mentioned3 cycles five min; three sessionsday for 3 days 2 cycles, five or 15 min (two cycles, 5 min; three cycles, five min; two cycles 15 min, three cycles 15 min)day for 1 day 3 cycles, five minday for three daysBrain ischemia was induced quickly soon after the last LRIpreC operationLeft typical carotid artery(86)SD ratsMale, 27030 gBrain5 Isoflurane and maintained with 11 IsofluraneBrain ischemia was Left hind limb induced instantly or 12 h, two d after LRIpreCNo specific pathway talked about(41) Remote Ischemic ConditioningWistar ratsMale, 24060 gHeartUrethane 1 gkgChloral Hydrate 0.three gkgAt dayLeft hind limbDecreased leakage of myocardial enzymes(87) (Continued)TABLe 1 | Continued Animal Sex, age, physique weight Male, 28020 g Unsexed pups, 15000 g Male, 80 weeks ischemic organ Brain Anesthetic employed before ischemia 5 Isoflurane and maintained with 2.five Thiopental 35 mgkg Pentobarbital 60 mgkg Anesthetic employed in the course of RiC two.5 Isoflurane RiC protocolday when RiC was started At 1 h just before HS-27 Formula middle cerebral artery occlusion (MCAO) At ten min prior to the heart ischemia Collected blood sample at five min (LRIpreC5) or 10 min (LRIpreC10) after limb ischemia RiC organ Major pathway investigated Important alterations in peripheral immune responses TRPV1 channels ReferenceFrontiers in Neurology | www.frontiersin.org 8 February 2018 | Volume 9 | ArticleChen et al.SD rats4 cycles, five minday for 1 day four cycles, five minday for 1 day ten min limb ischemia followed by 5 min (LRIpreC5) or ten min (LRIpreC10) reperfusionday for 1 day 3 cycles, 15.