Min day for 1 dayBilateral hind limb(88)Wistar ratsHeartNot mentionedHind limb(89)Wistar ratsLimbNot mentionedRight femoral arteryEffect on plasma proteome(90)SD ratsMale, 27030 gBrain5 Isoflurane and maintained with 1 Thiopental 35 mgkg1 IsofluraneAt 1.5 h ahead of dMCAOLeft femoral arteryExtrinsic apoptotic 17a-Hydroxypregnenolone Technical Information pathway and TNF-related apoptosis-inducing ligand receptors expression Activation of mechanosensitive TRP and particularly TRPV channels Circulating elements released by visceral organs(40)Wistar ratsMale, 15000 gHeartNot mentioned5 cycles, five minday for 1 dayHeart ischemia was induced right away immediately after LRIpreC Heart ischemia was induced quickly soon after LRIpreCHind limb(91)SD ratsMale, 28020 gHeartPentobarbital 60 mgkgPentobarbital, 105 mgkg15 min occlusion followed by 10 min reperfusionday for 1 day four cycles, ten min day for 1 dayBoth hind limbs(92)Limb remote ischemic perconditioning (LRIperC)C57BL6J Female, mice, 20 two weeks ovariectomized C57BL6J mice SD rats Male, 20 1 weeks Male, Postnatal dayBrainMild Isoflurane; dose not mentioned three.5 isoflurane and maintained with 1.five 2.0 Ketamine Hydrochloride 8000 mg kg and Acepromazine Maleate 5 mgkg 10 Chloral HydrateNot mentionedAt 2 h poststrokeLimbNo distinct pathway described(53)BrainNot mentioned5 cycles, 5 minday for 1 day 4 cycles, 5 minday for 1 dayAt two h soon after embolic MCAO At 40 min prior to MCAOLeft limbNo particular pathway described(93)BrainNot mentionedLeft hind limb(94) Remote Ischemic ConditioningSD ratsMale, 25080 gBrainNot mentioned4 cycles, 5 minday for 1 dayAt 40 min prior to reperfusionLeft hind limbInhibits autophagy to attenuate plasma higher mobility group box 1 and induce neuroprotection(51)(Continued)Chen et al.Remote Ischemic ConditioningTABLe 1 | ContinuedWistar ratsAnimalSD ratsFor LRIperC, Costa et al. utilized combined LRIperC and regional postconditioning in rats that underwent 60 min of liver ischemia (104). The procedure consisted of four cycles of 5-min hind limb ischemia and 5-min perfusion; local postconditioning consisted of four cycles of 5-min liver ischemia followed by 5-min perfusion. Final results showed that the mixture of LRIperC and regional postconditioning was in a position to lower hepatic tissue MDA levels and additional attenuate IR injury (104). For LRIP, Li et al. used CD1 mice to prove that LRIP could significantly reduce the IR injury by way of upregulation and expression of Nrf2 in addition to heme oxygenase 1 (HO1), quinone oxidoreductase 1 (NQO1), and superoxide dismutase (SOD), all cytoprotective enzymes downstream of Nrf2 (52). Their group applied mice to conduct 3 cycles of 5-min ischemia and subsequent 5-min reperfusion of bilateral femoral arteries to show that LRIP considerably enhanced neurological outcomes likely by decreasing oxidative strain and initiating the Nrf2-ARE pathway. Zhang et al., Zhou et al., and Kadkhodaee et al. all investigated the effect of LRIP against IR injury in rats; all Methyl nicotinate Purity groups showed a substantial decrease inside the level of MDA soon after LRIP (64, 105, 106). We performed research in rats to understand the function of nitrotyrosine, mRNA of P22phox, and xanthine oxidase and how they contribute to oxidative harm. During 3 cycles of 15-min occlusion and subsequent 15-min reperfusion of the left femoral artery, the levels of those 3 oxidants had been decreased by LRIP. Additional experimentation proved that LRIP could reverse the eNOS uncoupling to reduce the IR injury caused by the aforementioned oxidants (43). Other researchers also proved.