Al number of patients Age (years) 50 509 609 70 Pathological stage T2a T2b T2c Gleason score 7p Value0.Snail image score eight 29 a high 6 (28.six) Figure three. Sensitivity and specificity of achieve of(90.six) Gleason score or high pAkt0.035 in specimens with 6 three (9.4) 15(AUC) for higher pAkt image score (71.4) respect to biochemical recurrence (BRC). Places beneath the ROC Recurrence 18 and 7 (33.3) 0.012 (eight) and higher Gleason score (7) have been 0.62 (56.3) 0.624, indicating similar discriminatory skills PSA, mean (ngmL) 29.9 12.1 0.026 for BRC.PSA: prostate certain antigen.In accordance with the KaplanMeier test, we observed that individuals with larger pAkt expression According to the had shorter test, we observed that patients with greater to these with (with (with scores of eight) KaplanMeierrecurrencefree survival times comparedpAkt expression decrease scores of 8) hadscores ofrecurrencefree survival occasions in comparison to who had greater pAkt tumor expression (with shorter six) of your protein (Figure 4A). For sufferers those with lower expression (with scores of 6) from the protein (Figure 4A). For patients who had higher pAkt tumor people that expression, the median recurrencefree survival was 62 months, whereas for expression, the median recurrencefree survival was 62 months, whereas for those who demonstrated reduced pAkt demonstrated lower pAkt tumor expression, it was 88 months (p = 0.03) (Figure 4A). Additionally, tumor expression, it was 88 months (p = 0.03) that patients Moreover, outcomes of the KaplanMeier test final results of the KaplanMeier test also showed (Figure 4A). using a greater Gleason score sum (of 7) or also showed that individuals with a greater Gleason all had considerably a higher recurrencefree survival a greater Snail expression (having a score of 8) score sum (of 7) or shorter Snail expression (with a score of 8)0.03had drastically shorter recurrencefree survival timesthe = 0.03 and 0.05) KaplanMeier times (p = all and 0.05) (Figure 4B,C). These final results showed that (p p worth from the (Figure 4B,C). These benefits showed that the p value of your KaplanMeier same and smaller sized than the higher Gleason test utilized to compare the greater pAkt group was the test Brca1 Inhibitors products employed to examine the higher pAkt group was the sameand larger Snail group, respectively. score group and larger Snail group, respectively. score group and smaller sized than the higher GleasonFigure 4. Cont. Figure 4. Cont.Int. J. Mol. Sci. 2016, 17, 1194 Int. J. Mol. Sci. 2016, 17,7 of 12 7 ofFigure four. KaplanMeier survival curves displaying relationships of the phosphorylated (p)Akt image Figure 4. KaplanMeier survival curves showing relationships on the phosphorylated (p)Akt image score (A), Gleason score sum (B), and Snail image score (C) in key tumors with recurrencefree score (A), Gleason score sum (B), and Snail image score (C) in main tumors with recurrencefree survival in sufferers with clinicallylocalized prostate cancer. The recurrencefree survival of patients survival in 5353 sufferers with clinicallylocalized prostate cancer. The recurrencefree survival of using a greater pAkt, Snail image score (eight) score (eight) or Gleason (7) was significantlysignificantly individuals having a higher pAkt, Snail image or Gleason score sum score sum (7) was lower than that of than that having a decrease pAkt, SnailpAkt, Snail imageor Gleason or Gleason (6) (p 0.05, lower individuals of individuals having a reduce image score (six) score (6) score sum score sum (6) logrank test). (p 0.05, logrank test).A Cox proportional hazard model was carried out further ex.