Acy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid
Acy of bosutinib (SKI-606) in continual phase Philadelphia chromosome-positive persistent myeloid leukemia individuals with resistance or intolerance to imatinib. Blood, 2011; 118: 45676 six. Berman E, Nicolaides M, Maki RG et al: Altered bone and mineral metabolism in individuals obtaining imatinib mesylate. N Engl J Med, 2006; 354: 20063 seven. Fitter S, Dewar AL, Kostakis P et al: Long-term imatinib therapy promotes bone formation in CML individuals. Blood, 2008; 111: 25387 8. Mariani S, Giona F, Basciani S et al: Low bone density and decreased inhibin-BFSH ratio within a boy taken care of with imatinib during puberty. Lancet, 2008; 372: 1112 9. Schmid H, J er B, Lohse J, Suttorp M: Longitudinal development retardation in the prepupertal woman with chronic myeloid leukemia on long-term imatinib therapy. Haematologica, 2009; 94: 11779 ten. Kimoto T, Inoue M, Kawa K: Growth deceleration within a woman taken care of with imatinib. Int J Hematol, 2009; 89: 2512 11. ALK3 manufacturer Millot F, Baruchel A, Guilhot J et al: Imatinib is productive but features a detrimental effect on development in children with previously untreated persistent myelogenous leukaemia (CML) in early continual phase (CP): success of your French national phase IV trial. (abstract) Blood, 2009; 114: 356 twelve. Dewar AL, Cambareri AC, Zannettino AC et al: Macrophage colony-stimulating element receptor c-fms is usually a novel target of imatinib. Blood, 2005; 105: 31272 13. Knight B, Tirnitz-Parker JE, Olynyk JK: C-kit inhibition by imatinib mesylate attenuates progenitor cell expansion and inhibits liver tumor formation in mice. Gastroenterology, 2008; 135: 9699 14. Tibullo D, Barbagallo I, Giallongo C et al: Results of second-generation tyrosine COX-2 custom synthesis kinase inhibitors in direction of osteogenic differentiation of human mesenchymal cells of healthy donors. Hematol Oncol, 2012; 30: 273 15. Puttini M, Coluccia AM, Boschelli F et al: In vitro and in vivo activity of SKI606, a novel Src-Abl inhibitor, towards imatinib-resistant Bcr-Abl neoplastic cells. Cancer Res, 2006; 66: 113142 sixteen. Quintas-Cardama A, Kantarjian H, Cortes J: Flying beneath the radar: the brand new wave of BCR-ABL inhibitors. Nat Rev Drug Discov, 2007; six: 8348 17. Pfizer Laboratories. Pharmacology Toxicology NDA Assessment and Evaluation. Meals and Drug Administration (FDA) Center for Drug Evaluation and Investigation. NDA 2011 ID: 203341 Out there from: URL: drugsatfda_docsnda2012203341Orig1s000PharmR.pdf 18. Tauer JT, K ig S, Hofbauer LC, Suttorp M: A rat model to predict alterations in bone growth and metabolism in little ones with CML on imatinib. Haematologica, 2011; 96: 28 (abstract) 19. Cortes JE, Kim DW, Kantarjian HM et al: Bosutinib versus imatinib in newly diagnosed chronic-phase persistent myeloid leukemia: benefits in the BELA trial. J Clin Oncol, 2012; thirty: 34862 twenty. Tibullo D, Giallongo C, La CP et al: Effects of imatinib mesylate in osteoblastogenesis. Exp Hematol, 2009; 37: 4618 21. Id BH, Lagneaux L, Najar M, Piccart M et al: The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts. BMC Cancer, 2010; 10: 298 22. Vandyke K, Dewar AL, Diamond P et al: The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling by inhibition of osteoclasts in vivo. J Bone Miner Res, 2010; 25: 17590 23. O’Sullivan S, Lin JM, Watson M et al: The skeletal effects of your tyrosine kinase inhibitor nilotinib. Bone, 2011; 49: 2819 24. Tokunaga A, Oya T, Ishii Y et al: PDGF receptor beta is often a potent regulator of mesenchymal stromal.