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Research papERREsEaRch papEREpigenetics eight:7, 703?09; July 2013; ?2013 Landes BioscienceComparison of epigenetic profiles of human oral epithelial cells from HIV-positive (on HAART) and HIV-negative subjectssantosh K. Ghosh,1, Thomas s. Mccormick,1,2 Betty L. Eapen,1 Elizabeth Yohannes,three Mark R. chance3 and aaron Weinberg1,Division of Biological sciences; case Western Reserve mTORC1 Activator supplier University; cleveland, Oh Usa; 2Department of Dermatology; case Western Reserve University; cleveland, Oh Usa; three center for proteomics and Bioinformatics; case Western Reserve University; cleveland, Oh UsaKeywords: oral epithelium, HIV, HAART, DNMTs, HDAC-1, hBD-hIV-infected subjects on extremely active antiretroviral therapy (haaRT) are susceptible to comorbid microbial infections within the oral cavity. We observed that principal oral epithelial cells (pOEcs) isolated from hIV+ subjects on haaRT develop more slowly and are significantly less innate immune responsive to microbial challenge when compared with pOEcs from regular subjects. These aberrant cells also demonstrate epigenetic variations that incorporate reduction in histone deacetylase 1 (hDac-1) levels and reduced total DNa methyltransferase (DNMT) activity precise to enzymes DNMT1 and DNMT3a. The DNMT activity correlates properly with glob.