Product Name :
Mouse anti Human CD38, conjugated with FITC

Description :
| Clone TME-2 | Isotype IgG1 | Product Type Single-Color Reagent | Units 100 Tests | Host Mouse | Species Reactivity Human | Application Flow Cytometry

Background :

Source :
CD38 antigen is an integral membrane glycoprotein, M.W. 45 kD. The CD38 antigen is present on approximately all pre-B lymphocytes, plasma cells and thymocytes. CD38 antigen is also expressed on activated T Lymphocytes, NK Cells, monocytes, myeloblasts and erythroblasts. CD38 is co-expressed on CD34+ cells,but is not expressed on pluripotent stem cells. CD38 antigen is present on T and B lymphoblastic leukemia (ALL), Burkitts’ lymphoma, multiple myeloma and acute myeloid leukemia (AML). Synonyms: CD38FITC <

Product :
Product Form: FITC Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide and 0.2% carrier protein Purification Method: Protein A/G Chromatography Concentration: Titered for flow cytometry

Specificity :

Applications :
PBMC: Add 10 µl of MAB/10^6 PBMC in 100 µl PBS. Mix gently and incubate for 15 minutes at 2° to 8°C. Wash twice with PBS and analyze or fix with 0.5% v/v of paraformaldehyde in PBS and analyze. WHOLE BLOOD: Add 10 µl of MAB/100 µl of whole blood. Mix gently and incubate for 15 minutes at room temperature (20°C). Lyse the whole blood. Wash once with PBS and analyze or fix with 0.5% v/v of paraformaldehyde in PBS and analyze. See instrument manufacturer’s instructions for Lysed Whole Blood and Immunofluorescence analysis with a flow cytometer or microscope. Functional Analysis: Flow Cytometry Staining

Storage :
Product should be stored at 4-8°C. DO NOT FREEZE Product Stability: See expiration date on vial Shipping Conditions: Room Temperature

Caution :
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.

References :
1) CD38 Molecule: Structural and Biochemical Analysis on Human T Lymphocytes, Thymocytes and Plasma Cells. J. Immunol, 1990 Aug; 145(3):878-84. Alessio, M. Roggero, S.; Funaro, A. ; De Monte L.B.,: Peruzzi, L.; Geuna, M.; Malavasi,F. 2) Differences Amoung Mononuclear Cell Subpopulations in HIV Seropositive or Seronegative Homosexual and Heterosexual men as Determined by Four Color Flow Cytometry. J. Acquir Immume Defic Syndr., 1990;3(8):747-56. Schnizlein-Bick, C.T.; Magier, M.R.; Jones, R.B.; Fife, K.H.; Katz, B., P.; Walker, E.B. 3) Quantitative Comparison of Myeloid Antigens on Five Lineages of Mature Peripheral Blood Cells. J. Leukoc Bio. 1990, Au;48(2):13848. Terstappen, L.W.; Hollander, Z.; Meiners, H.; Loken, M.R. 4) B-cell Surface Phenotypes of Proliferating Myeloma Cells: Target Antigens for Immunotherapy. Am. J. Hematol. 1990, Fe;33(2):1019, Chan, C.S; Wormsley, S.B.; Pierce, L. E.; Peter, J.B.; Schechter, G.P. 5) Interrelationships Between Serologic Markers of Immune Activation and T Lymphocyte Subsets in HIV Infection. J. Acquir Immune Defic Syndr. 1990;3(5):525-30. Prince, H.E.; Kleinman, S. Czaplicki, C.; John, J.; Williams, A.E. 6) Sequential Gererations of Hematopoietic Colonies Derived from Single Nonlineage-committed CD34+ CD38- Progenitor Cells. Blood 1991, Mar 1;77(6):1218-27. Terstappen, L.W.; huang, S.; Safford, M. Lansdorp, P.M.; Loken, M.R. 7) Involvement of Multilineage CD38 Molecule in a Unique Pathway of Cell Activation and Proliferation. J. Immunol, 1990 Oct 1;145(8):2390-6Funaro, A.; Spagnoli, G.C.; Ausiello, C.M.; Alessio, M.; Roggero, S.; Delia, D.; Zaccolo, M.; Malavasi, F. 8) Induction of CD4 and Susceptibility to HIV-1 Infection in Human CD8+ T Lymphocytes by Human Herpesvirus 6. Nat.349(6309): 5335, 1991. Lusso, P.; De Maria, A.; Malnati, M.; Lori, F.; DeRocco, S.E.;Baseler, M.; Gallo, R.C. 9) Circulating Antigen-Specific Suppressor T Cells in a Healthy Woman: Mechanism of Action and Isolation with a Monoclonal Antibody. Clin. Res. 29, 365a, 1981. Engleman, E. G.; Benike, C. J.; Evans, R.L 10) CD4 and CD8 Molecules Can Physically Associate with the Same T-cell Receptor. Proc. Nat. Acad. Sci. 1989, 86:10044.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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