Product Name :
Mouse anti Yeast (Saccharomyces cerevisiae) TUP1

Description :
| Clone 10 | Isotype IgG | Product Type Monoclonal Antibody | Units 100 µg | Host Mouse | Species Reactivity Yeast (Saccharomyces cerevisiae) | Application Western Blotting

Background :
Immunogen: Recombinant protein derived from the amino acids 1-200 of yeastt TUP1 protein

Source :
Yeast Tup 1p-Ssn6p repressor complex represents a novel paradigm for transcriptional repression and for the role of chromatin in repression. TUP 1 and SSN6 are involved in repression of several diverse families of genes in yeast, including cell type-specific genes regulated by the alphga2 and a1/alpha2 repressors. Ssn6-Tupl interacts with class I histone deacetylases required for repression, and rfecrfuitment of yeast Tuplp-Ssn6p repressor is associated with localized decreases in histone acetylation. Synonyms: General transcriptional corepressor TUP1, Glucose repression regulatory protein TUP1, Flocculation suppressor protein, Repressor AER2, TUP1, AAR1, AER2, AMM1, CYC9, FLK1, SFL2, UMR7, YCR084C, YCR84 <

Product :
Product Form: Unconjugated Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide Purification Method: Protein A/G Chromatography Concentration: See vial for concentration

Specificity :

Applications :
Antibody can be used for Western blotting (5-10 µg/ml). Optimal concentration should be evaluated by serial dilutions. Functional Analysis: Western Blotting Positive Control: Mav108 cells expressing recombinant TUP1 protein

Storage :
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles Product Stability: See expiration date on vial Shipping Conditions: Ship at ambient temperature, freeze upon arrival

Caution :
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.

References :
1. Bone, J.R. and Roth, S.Y. ‘Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation.’ J. Biol. Chem 2001, 276, 1808-1813 2. Watson, A.D., et al. ‘Ssn6-Tup1 interacts with class I histone deacetylase required for repression.’ Genes and Development 2000, 14, 2737-2744 3. Yang, X., et al. ‘Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: Coupling protein O-GlcNAcylation to transcriptional repressor.’ Cell 2002, 110, 69-80 4. DeSilva, H., et al. ‘Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor.’ Genetics 1998, 148, 657-667

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites:
Popular product recommendations:
Lactate Dehydrogenase Antibody
MTNR1A Antibody: MTNR1A Antibody is an unconjugated, approximately 39 kDa, rabbit-derived, anti-MTNR1A polyclonal antibody. MTNR1A Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, and predicted: chicken, dog, pig, cow, sheep, guinea pig background without labeling.