Product Name :
Rabbit anti Human G-Protein Coupled Receptor 94
Description :
| Product Type Antigen Immunoaffinity Purified Polyclonal | Units 100 µg | Host Rabbit | Species Reactivity Human | Application Western Blotting
Background :
Immunogen: Synthetic peptide derived from human GPCR94.
Source :
Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system. Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined. Stimulation by ADP in stably transfected CHO cells resulted in inhibition of adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are transduction mechanisms that involve G(i) proteins. Synonyms: P2Y Purinoceptor 13; P2Y13; G-protein coupled receptor 86; GPCR94; GPCR86 <
Product :
Product Form: Affinity Purified Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide Purification Method: Antigen Immunoaffiinity Purification Concentration: Lot specific, see vial
Specificity :
Applications :
Antibody can be used for Western blotting (1:400 starting dilution) and immunohistochemistry (10-15 µg/ml). Optimal concentration should be evaluated by serial dilutions. Functional Analysis: Western Blotting Positive Control: Normal human brain
Storage :
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles Product Stability: See expiration date on vial Shipping Conditions: Ship at ambient temperature, freeze upon arrival
Caution :
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.
References :
1. Communi, D, et al. Identification of a novel human ADP receptor coupled to Gi.; J. Biol. Chem. 276:41479-41485(2001).
Related websites: https://www.medchemexpress.com/antibodies.html
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