Product Name :
Rabbit anti Human Lipid Phosphate Phosphohydrolase 2
Description :
| Isotype IgG | Product Type Antigen Immunoaffinity Purified Polyclonal | Units 100 µg | Host Rabbit | Species Reactivity Human Porcine | Application Enzyme Immunoassay Western Blotting
Background :
Immunogen: Synthetic peptide derived from the lipid phosphate phosphohydrolase 2 protein
Source :
Phosphatidic acid (PA), lysophosphatidic acid, ceramide 1-phosphate (C1P), and sphingosine 1-phosphate (S1P) are lipid mediators generated by phospholipases, sphingomyelinases, and lipid kinases. The major pathway for degradation of these lipids is dephosphorylation catalyzed by members of two classes (types 1 and 2) of phosphohydrolase activities (PAPs). cDNAs encoding two type 2 PAPs, PAP-2a and -2b, have been expressed by transient transfection and shown to catalyze hydrolysis of PA, C1P, and S1P. Synonyms: Pan Phosphatidic Acid Phosphatase 2C; Pan PPAP <
Product :
Product Form: Unconjugated Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide Purification Method: Antigen Immunoaffiinity Purification Concentration: Lot specific, see vial
Specificity :
Applications :
Antibody can be used for Western blotting (see vial for dilution) and EIA. Optimal concentration should be evaluated by serial dilutions. Functional Analysis: Western Blotting Positive Control: Human brain lysate (Cat. No. X1633C)
Storage :
Product should be stored at -70°C. Aliquot to avoid freeze/thaw cycles Product Stability: See expiration date on vial Shipping Conditions: Ship at ambient temperature, freeze upon arrival
Caution :
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.
References :
[1] Leung D.W., Tompkins C.K., White T.; Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.; DNA Cell Biol. 17:377-385(1998). [2] Roberts R., Sciorra V.A., Morris A.J.; Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.; J. Biol. Chem. 273:22059-22067(1998). [3] Hooks S.B., Ragan S.P., Lynch K.R.; Identification of a novel human phosphatidic acid phosphatase type 2 isoform.; FEBS Lett. 427:188-192(1998). [4] Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.; Cloning of human full-length CDSs in BD Creator(TM) system donor vector.; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. [5] Strausberg R.L., et al Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.; Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
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