Product Name :
Rabbit anti Human LNX1
Description :
| Product Type Polyclonal Antibody | Units 100 µg | Host Rabbit | Species Reactivity Human | Application Western Blotting
Background :
Immunogen: Synthetic peptide derived from the human LNX1 protein.
Source :
LNX1 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 Synonyms: Numb-binding protein 1; Ligand of Numb-protein X 1 <
Product :
Product Form: Unconjugated Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide Purification Method: Ammonium Sulfate Precipitation Concentration: See vial for concentration
Specificity :
Applications :
Antibody can be used for Western blotting (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions. Functional Analysis: Western Blotting Positive Control: Protein expressed in heart, placenta, kidney, pancreas and brain.
Storage :
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles Product Stability: See expiration date on vial Shipping Conditions: Ship at ambient temperature, freeze upon arrival
Caution :
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.
References :
1. Armbruester, V., et al. ‘Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X.; J. Virol. 78:10310-10319(2004). 2. Sollerbrant, K., et al. ‘The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX).; J. Biol. Chem. 278:7439-7444(2003). 3. Xie, Y., et al. ‘Identification of a human LNX protein containing multiple PDZ domains.; Biochem. Genet. 39:117-126(2001).
Related websites: https://www.medchemexpress.com/antibodies.html
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