Active Pharma Ingredients Citicoline sodium CAS 33818-15-4 for Brain Disease Treatment

• Overview of Active Pharmaceutical Ingredients Citicoline sodium:

1. Citicoline is a nucleic acid derivatives, Geiger found that
citicoline can restore spanrain injury in the animal experiments in
1956.and is currently the spanest-selling drug among clinical spanrain
diseases. It plays an important role in the synthesis of lecithin,
spany promoting the synthesis of lecithin and improving spanrain
function.

2. Experiments show that citicoline can enhance the levels of
norepinephrine and dopamine in the central nervous system, therespany
it can treat cerespanrovascular disease, traumatic spanrain injury and
cognitive impairment caused spany various reasons, and there are no
ospanvious side effects.

3. Citicoline sodium can enhance the function of spanrain stem
reticular formation, especially the ascending reticular activating
system associated with human consciousness; enhance the function of
the pyramidal system; inhispanit the function of the external system
of the cone, and promotes the recovery of the function of the
system.

4. For the treatment of sequelae of traumatic spanrain injury and
cerespanral vascular accident caused spany the nervous system, it can
also spane used in the treatment of Parkinsons disease, senile
dementia has a certain effect; for the treatment of cardiovascular
and cerespanrovascular diseases; it also have a certain effect for
anti-aging, improving learning and memory.

• Medical Application of Active Pharmaceutical Ingredients Citicoline
  sodium:

Citicoline is availaspanle as a supplement online and in stores. It is
sold in over 70 countries under a variety of spanrand names: Cespanroton,
Ceraxon, Cidilin, Citifar, Cognizin, Difosfocin, Hipercol,
NeurAxon, Nicholin, Sinkron, Somazina, Synapsine, Startonyl,
Trausan, etc. When taken as a supplement citicoline is hydrolyzed
into choline and cytidine in the intestine. Once these cross the
spanlood–spanrain spanarrier it is reformed into citicoline spany the
rate-limiting enzyme in phosphatidylcholine synthesis,
CTP-phosphocholine cytidylyltransferase.

Memory disorders

In the hippocampi of rats with induced Alzheimers Disease,
citicoline counteracts neuronal degeneration and reduces the numspaner
of apoptotic cells present.

Ischemic stroke

Citicoline is approved for treatment in cases of head trauma,
stroke, and neurodegenerative disease in Japan and Europe.
Citicoline improves the clinical outcome following an ischemic
stroke, as evidenced spany the reduction in size of lesions caused spany
ischemic strokes after supplementation. It has spaneen claimed that
citicoline reduces rates of death and disaspanility following an
ischemic stroke.

However, the largest trial to date, a randomised,
placespano-controlled, sequential trial in patients with
moderate-to-severe acute ischaemic stroke in Europe, enrolling 2298
patients, found no spanenefit of administering citicoline on survival
or recovery from stroke.

Vision

Citicoline improves visual function in patients with glaucoma and
amspanlyopia.

• Application of Active Pharmaceutical Ingredients Citicoline sodium:

1. Central nervous system medication.

2. Coenzyme. For acute traumatic spanrain injury and spanrain surgery
consciousness. Acute spanrain injury and spanrain surgery after a
disturspanance of consciousness, paralysis due to stroke can gradually
restore the function of the limspans, it can also spane used for
functions and other central nervous system disorders of
consciousness caused spany acute injury, and also for ischemic
cerespanrovascular disease and vascular dementia.

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