ds, which includes chemical, physical, and bio-based green approaches (sunlight irradiation, from bacteria, fungi, yeast, algae, and plants) [110]. As already talked about above, top-down and bottom-up approaches are amongst the easiest. As a result of reality that inorganic nanoparticles are already used in diagnostic medicine and imaging, scaling up their production is a reality, although not totally free from charges. As they consist of a repetition of monomeric interior units encircled by the outermost region, dendrimers are usually synthesized by a sequential repeat of reaction measures. Indeed, they are formed of a core, from which numerous spacers depart, whose ends combine with a high degree of branching that allows surface chemistry functionalization with proteins, amino acids, fatty acids, and polymers as a way to enhance solubility and lessen toxicity [184,185]. The usage of dendrimers as drug carriers is still the subject of study, although recent applications include nanomedicines, gene-delivery vectors, biological adhesives, and imaging agents [137,18588]. Lastly, SMEDDSs belong towards the emulsion class because they are dry microemulsions without the need of an aqueous phase and they’ve the excellent benefit to spontaneously kind emulsions in vivo without having any power input [86,137]. In accordance with their higher targeting efficiency, it’s achievable to decrease the drug amount required to have a clinical effect, thereby enhancing patient compliance as well as the expense of therapy [137]. Taking these evaluations into account and taking into consideration the absence of information with regards to some aspects from the newest drug delivery approaches, it can be proper to affirm that nanoemulsions are, at present, by far the most suitable, well-investigated, and low-cost strategy to improve bioavailability of curcumin, either as a drug or maybe a dietary supplement to enrich food and beverages. four. Conclusions At the moment, the polyphenolic compound curcumin is one of the most investigated organic items and its helpful effects in numerous human problems happen to be established, together with a low toxic profile. During the years, many curcumin drug targets have already been described, supplying the molecular basis for the pharmacological action. Unfortunately, the bioavailability and delivery of curcumin would be the principal obstacles for its effectiveness, precluding the use in medicine. In this evaluation, we’ve got explored probably the most promising and modern day approaches for enhancing curcumin bioavailability, providing a extensive overview relating to this field. Surely, the progress within the nanoparticle field could deliver, within the close to future, further curcumin-based CBP/p300 Activator drug complexes with significant pharmacological profiles that could be created as efficient therapeutic agents for treating human illnesses. The advancement in this field holds excellent promise to employ this polyphenol in medicine. Furthermore, as a result of multifunctional profile of curcumin, an efficacious delivery strategy could supply a superior possibility of powerful prophylaxis or treatment in complex multifactorial issues, such as systemic inflammatory diseases and cancer, supporting the curcumin-based agents as D1 Receptor Antagonist supplier preventive and disease-modifying therapeutics.Pharmaceutics 2021, 13,29 ofAuthor Contributions: Conceptualization, R.T., S.B. and V.C.; investigation, R.T. and S.B.; data curation, R.T., S.B. and V.C.; writing–original draft preparation, R.T. and S.B.; writing–review and editing, R.T., S.B. and V.C.; supervision, S.B. All authors have read and agreed towards the published version of the man