L as esophageal adenocarcinoma (EAC), may be the principal histological forms of EC. In China, ESCC would be the most predominant subtype with high incidences, accounting for 90 of newly diagnosed EC instances [3, 4]. To date, the prognosis among patients suffering from ESCC is still poor, having a 5-year all round survival (OS) rate of significantly less than 25 [5]. A much better comprehension of the underlying mechanism of ESCC pathogenesis can facilitate the building of novel therapeutic and diagnostic techniques to enhance ESCC outcome. TAB182, also referred to as TNKS1BP1, was first discovered as a tankyrase 1-binding protein that acts as an receptor of poly (ADPribosyl) action by tankyrase 1 [6]. Not too long ago, Zhong et al. reported that TAB182 is up-regulated in lung adenocarcinoma and affects lung adenocarcinoma cells’ sensitivity to DNA damage regent via regulating the homologous recombination pathway of DNA double-strand breaks (DSB) [7]. Additionally, Zhou and colleagues discovered that TAB182 may very well be induced by ionizingradiation (IR), and TAB182 is essential for the effective repair of IRmediated DSB through enhancing DNA-PKcs’ interacting with PARP-1 [8]. Our previous study showed that TAB182 heightens the radioresistance of ESCC cells by mediating the G2-M checkpoint via its interaction with FHL2 [9]. Although recent research have revealed the vital roles of TAB182 in DNA damage response, no matter whether and how TAB182 associates with ESCC tumorigenesis and progression stay unclear. FHL2 is a multifunctional scaffolding protein that belongs to the four-and-a-half LIM domains protein household. FHL2 has been discovered to interact with multiple sorts of proteins as a result of its special structure that consists of several LIM motifs, like IER3 and MDM2 [10], EGFR, and EGFRvIII [11]. Additionally, it is reported that the zinc-finger motif in the LIM domain confers FHL2 with transcriptional repressor or co-activator function [12, 13]. Consequently, FHL2 is involved within the modulation of varied cellular processes, such as gene expression, cell proliferation and motility [14]. Interestingly, accumulating proof has demonstrated the essential roles of FHL2 in tumorigenesis plus the progression of carcinoma within a context-dependent manner. For example, it exerts oncogenic function in ovarian cancer [15], cervical cancer [10], and gastrointestinal cancer [16], but exhibits a tumor-suppressiveSuzhou Cancer Center Core Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, P.SLPI Protein Storage & Stability R.BNP Protein supplier China. 2The Affiliated Suqian Hospital of Xuzhou Health-related University and Nanjing Drum Tower Hospital Group Suqian Hospital, Suqian, Jiangsu, P.R. China. 3School of Radiation Medicine and Protection, Healthcare College of Soochow University, Suzhou, China.PMID:25040798 4Department of Pathology, University of Oklahoma Well being Science Center, Oklahoma City, OK, USA. 5Department of Thoracic Surgery, Initial Affiliated Hospital of Nanjing Healthcare University, Nanjing, China. 6Suzhou Cancer Center Core Laboratory, The Affiliated Suzhou Hospital of Nanjing Healthcare University, Suzhou Municipal Hospital, Gusu College, Baita west road 16, 215001 Suzhou, China. 7These authors contributed equally: Aidi Gao, Zhenzi Su, Zengfu Shang. e-mail: chirurgeonzhouyue@163; sunming348@hotmail; zhoujundong330@163 Edited by Professor Nickolai BarlevReceived: 20 June 2022 Revised: 30 September 2022 Accepted: 10 October 2022 Published on the net: 26 OctoberOfficial journal of CDDpressA. Gao et al.two function in rhabdomyosarcoma [17] and h.