Product Name :
Mouse anti Human p21 WAF-1

Description :
| Clone DCS-60 | Isotype IgG2a | Product Type Monoclonal Antibody | Units 100 µg | Host Mouse | Species Reactivity Human | Application Immunohistochemistry Immunoprecipitation Western Blotting

Background :
Mice were immunized with a recombinant full length p21 protein.

Source :
The p21waf1 tumor suppressor protein shows no cross reactivity with the closely related inhibitors .p21waf1 is a specific inhibitor of cdkÕs, and is a tumor suppressor involved in the pathogenesis of a number of malignancies including colon and breast carcinoma Synonyms: p21waf1; hp21; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6 <

Product :
Provided as solution in phosphate buffered saline with 0.08% sodium azide Product Form: Unconjugated Purification Method: Protein A/G Chromatography Concentration: See vial for concentration

Specificity :

Applications :
1-5 ug /ml for Western Blot, Immunoflurescence, Immunoprecipitation (co-precipitates cdk4/cdk6) Functional Analysis: Western Blotting

Storage :
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles Product Stability: See expiration date on vial Shipping Conditions: Ship at ambient temperature

Caution :
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.

References :
1) R. Erber, (1997) Pred. Oncol. 74, 383-389 2. Shen, J., et al. ‘Identification and Validation of Differences in Protein Levels in Normal, Premalignant, and Malignant Lung Cells and Tissues Using High-Throughput Western Array and Immunohistochemistry.’ Cancer Res., 66, 11194-11206 (2006).

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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